닥터심의 의학 칼럼: 코로나19 항체치료법 (에이즈ㆍ에볼라치료제Remdesivir와 비교) 우한 폐렴으로 불리는 신종 코로나 바이러스 감염질환을 치료할 수 있는 혁신적인 치료제와 치료법
곽영민 · 입력
* 본 영상은 2020.02.04 유튜브 닥터심 채널에 올렸던 영상입니다. 유튜브측에서 임의삭제를 해서 여기에 다시 올려드립니다.
항체 치료제에 대해서 최신 지견은 유튜브에 올리겠습니다.
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코로나19 항체치료법 (에이즈ㆍ에볼라치료제Remdesivir와 비교)
우한 폐렴으로 불리는 신종 코로나 바이러스 감염질환을 치료할 수 있는 혁신적인 치료제와 치료법을 소개합니다. 에이즈, 에볼라치료제, 혈장치료(혈청치료), 항체치료 모두 실존하는 치료법입니다. 우한 페렴은 치료법이 있는 질환입니다. 근거 논문과 함께 설명합니다.
1. Lopinavir/ritonavir https://en.wikipedia.org/wiki/Lopinavir/ritonavir
2. Lopinavir; A Potent Drug against Coronavirus Infection http://archcid.com/en/articles/13823.html
3. Role of lopinavir/ritonavir in the treatment of SARS https://www.ncbi.nlm.nih.gov/pubmed/14985565
4.Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China https://www.thelancet.com/.../PIIS0140-6736(20.../fulltext
5. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954302/
6. First Case of 2019 Novel Coronavirus in the United States https://www.nejm.org/doi/full/10.1056/NEJMoa2001191
7. Three drugs fairly effective on novel coronavirus at cellular level
https://www.youtube.com/watch?v=5-sDX7JGCUE (Lopinavir/ritonavir 와 oseltamivir의 혼합요법 후 not a cure but vastly improved 라고 말하고 있습니다. 즉, 치료된 것은 아니고 많이 호전된 것이라는 뜻입니다.)
8. Chloroquine https://en.wikipedia.org/wiki/Chloroquine
9. Potential inhibitors for 2019-nCoV coronavirus M protease
from clinically approved medicines https://www.biorxiv.org/.../2020.01.29.924100v1.full.pdf
10.Use of convalescent plasma therapy in SARS patients in Hong Kong. https://www.ncbi.nlm.nih.gov/pubmed/15616839
11. Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. https://www.ncbi.nlm.nih.gov/pubmed/15214887
12. Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital. https://www.ncbi.nlm.nih.gov/pubmed/16183666
13. Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994343/
14. Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease https://www.who.int/.../ebola/convalescent-treatment/en/
15.Organizing the Donation of Convalescent Plasma for a Therapeutic Clinical Trial on Ebola Virus Disease: The Experience in Guinea https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014273/
16. The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States https://www.researchgate.net/.../275359229_The_Use_of_TKM...
17. mAb114 https://en.wikipedia.org/wiki/MAb114
18. REGN-EB3 https://en.wikipedia.org/wiki/REGN-EB3
19. A Cure for Ebola? Two New Treatments Prove Highly Effective in Congo https://www.nytimes.com/.../health/ebola-outbreak-cure.html
20. 메르스바이러스 항체 치료제 개발 동향 http://www.cdc.go.kr/board.es?mid=a20602010000&bid=0034...
Development of therapeutic monoclonal antibodies against MERS-CoV infection
21. [메르스 비상] 환자 적어 속도 못내는 치료제 개발 http://dongascience.donga.com/news.php?idx=23868
22. Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
23. Scientists discover antibody that can neutralize 2019-nCoV coronavirus https://tass.com/science/1114179
24. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody https://www.biorxiv.org/content/10.1101/2020.01.28.923011v1
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